Understanding heart disease in people with long-term Type 1 diabetes
Official title: Characterization of cardiovascular diseases (CVD) in people with long duration Type 1 diabetes
Funded at Joslin Diabetes Center · NIH-10991330 · Data updated 2026-11-12
This study is looking at how heart disease develops in people who have had Type 1 diabetes for a long time, to find out what makes their risk different from those with Type 2 diabetes, and it’s for anyone with a long history of Type 1 diabetes who wants to understand more about their heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Joslin Diabetes Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 24, 2021 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $758,888 |
| NIH project number | 5R01HL161864-04 |
| Project ID | NIH-10991330 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with long-duration Type 1 diabetes, particularly those who may or may not have diabetic nephropathy.
✕Less likely to help
Patients with Type 2 diabetes or those without a history of diabetes may not benefit from this research.
What this research studies
This research investigates how cardiovascular diseases (CVD) develop in individuals with long-duration Type 1 diabetes (T1D). It aims to identify the unique risk factors and mechanisms that contribute to CVD in T1D compared to Type 2 diabetes. By analyzing data from a large cohort of individuals with over 50 years of T1D, the study will explore the relationship between diabetes-related complications, such as diabetic nephropathy, and heart disease. The research will utilize advanced imaging techniques and genetic analysis to better understand the underlying causes of CVD in this population.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for cardiovascular diseases in patients with Type 1 diabetes.
How similar studies have gone: Previous studies have shown that understanding the unique cardiovascular risks in diabetes can lead to significant advancements in patient care, suggesting this research could build on established findings.
Where this research is happening
-
Joslin Diabetes Center
Boston, United States Active
Researchers
- Principal investigator: King, George L — Joslin Diabetes Center
- Study coordinator: King, George L
Related research
Other NIH-funded projects on the same topics.
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Understanding what raises heart disease risk in people with well-controlled type 1 diabetes
Researchers are studying why some people with type 1 diabetes still develop heart disease even when traditional risk factors are controlled.
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Understanding Heart Disease Risks in People with Well-Controlled Type 1 Diabetes
This project looks at why people with Type 1 diabetes might still get heart disease, even when their other health factors are well-managed.
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Investigating cardiovascular disease risks in people with well-controlled type 1 diabetes
This study is looking into why people with well-managed type 1 diabetes still have a higher chance of heart problems, by comparing their heart and blood samples with those from people with type 2 diabetes and those without diabetes, to find out what makes their risks different.
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Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
-
Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
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Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.