Understanding Heart Device Infections
Staphylococcus aureus Cardiac Device Infections - From the Vascular Viewpoint
['FUNDING_OTHER'] · DUKE UNIVERSITY · NIH-11118943
This project aims to find better ways to prevent and quickly identify infections in heart devices for patients with advanced heart disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11118943 on ClinicalTrials.gov |
What this research studies
For patients with advanced heart disease, implanted cardiac devices are life-saving but carry a risk of infection, which often requires surgery to remove the device. Currently, it's hard to diagnose these infections early, leading to delays and serious complications. This research will look at blood samples from patients to find specific markers that show who is at risk for a heart device infection, especially after a Staphylococcus aureus bloodstream infection. We also want to understand why some patients get these infections and others don't, using new lab models.
Who could benefit from this research
Good fit: Patients with implanted cardiac devices who are at risk for or have experienced a Staphylococcus aureus bloodstream infection would be the focus of this research.
Not a fit: Patients without implanted cardiac devices or those who do not experience bacterial bloodstream infections would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to earlier diagnosis and treatment of heart device infections, potentially saving lives and reducing complications for patients.
How similar studies have performed: This project builds on the candidate's previous published work and uses a novel in vitro model system, suggesting a blend of established and innovative approaches.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MASKARINEC, STACEY A — DUKE UNIVERSITY
- Study coordinator: MASKARINEC, STACEY A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.