Understanding heart damage caused by certain cancer treatments
Mechanisms of Cardiotoxicity Associated with Covalent Kinase Inhibitors
['FUNDING_P01'] · STANFORD UNIVERSITY · NIH-10935739
This study is looking at how certain cancer treatments, especially a drug called ibrutinib, might cause heart issues like irregular heartbeats, and it aims to find ways to make these treatments safer for patients.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10935739 on ClinicalTrials.gov |
What this research studies
This research investigates how specific cancer treatments, known as kinase inhibitors, can lead to heart problems such as arrhythmias. By using advanced genetic tools and mouse models, the team aims to identify the mechanisms behind this heart toxicity, particularly focusing on a drug called ibrutinib. The study will also analyze clinical data to connect laboratory findings with real-world patient experiences. This comprehensive approach seeks to improve the safety of cancer therapies for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing treatment with kinase inhibitors who may be at risk for heart-related side effects.
Not a fit: Patients who are not receiving kinase inhibitors or do not have a history of cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer cancer treatments with fewer cardiovascular side effects for patients.
How similar studies have performed: Other research has shown promising results in understanding the cardiovascular effects of cancer treatments, but this specific focus on covalent kinase inhibitors is relatively novel.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WU, JOSEPH C. — STANFORD UNIVERSITY
- Study coordinator: WU, JOSEPH C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.