Understanding Heart Damage After a Heart Attack
Distinct Pathways of VPF/VEGF Receptors
This research aims to uncover the specific ways heart attacks lead to scarring and eventually heart failure, hoping to find new ways to protect your heart.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-11055467 on NIH RePORTER |
What this research studies
When someone has a heart attack, the heart muscle can become scarred, which may lead to heart failure over time. Our team is looking closely at a specific protein called Neuropilin-1 (NRP1), which plays a role in how the heart responds to injury, including inflammation and scarring. We are studying how NRP1 acts in different heart cells to understand its exact role in heart damage. By understanding these detailed processes, we hope to identify new targets for medicines that could prevent or treat heart failure after a heart attack.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the underlying causes of heart failure following a heart attack.
Not a fit: Patients not affected by heart attack-induced cardiac fibrosis or heart failure would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that prevent or reduce heart scarring and failure in patients who have experienced a heart attack.
How similar studies have performed: Previous work by this team has already thoroughly explained the role of Neuropilin-1 in heart damage, building a strong foundation for this current investigation.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Mukhopadhyay, Debabrata — Mayo Clinic Jacksonville
- Study coordinator: Mukhopadhyay, Debabrata
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.