Understanding heart changes related to aging and amyloidosis
Interplay of Myocardial Fibrosis and Cardiac TTR Amyloid in Age Related Cardiac Remodeling in MESA-Multi-Ethnic Study of Atherosclerosis
This study is looking at how certain heart conditions, like fibrosis and amyloidosis, affect heart health in older adults, using special imaging and tests to help find ways to detect and treat heart problems earlier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11094905 on NIH RePORTER |
What this research studies
This research investigates how myocardial fibrosis and cardiac transthyretin amyloidosis contribute to heart changes in older adults. By using advanced imaging techniques like MRI and specific biomarkers, the study aims to identify the relationship between these conditions and heart function. The goal is to enhance early detection and treatment strategies for heart failure and related complications in aging populations. Participants may undergo imaging and assessments to help clarify these associations.
Who could benefit from this research
Good fit: Ideal candidates include older adults who may be experiencing heart-related issues or have risk factors for cardiac amyloidosis.
Not a fit: Patients who are younger or do not have any signs of heart disease or amyloidosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and treatment options for heart failure in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of amyloidosis in heart conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Lima, Joao a C — Johns Hopkins University
- Study coordinator: Lima, Joao a C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.