Understanding heart changes in pulmonary arterial hypertension
Multiscale Modeling of Right Ventricular Fibrotic Remodeling in Pulmonary Arterial Hypertension
This study is looking at how pulmonary arterial hypertension (PAH) changes the right side of the heart and its tissues, using animal models to learn more about how these changes affect heart function, with the hope of finding new ways to help people with PAH.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11010849 on NIH RePORTER |
What this research studies
This research investigates how pulmonary arterial hypertension (PAH) affects the heart's right ventricle by examining the structural and mechanical changes in heart tissue. Using animal models, the study will explore how the remodeling of the extracellular matrix (ECM) in the heart impacts its function and the behavior of cardiac fibroblasts, which are cells involved in heart tissue repair. The researchers will conduct detailed physiological studies and biomechanical tests to understand these changes over time, aiming to develop insights that could lead to new therapeutic strategies for PAH.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension.
Not a fit: Patients with other forms of heart disease unrelated to pulmonary arterial hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent right heart failure in patients with pulmonary arterial hypertension.
How similar studies have performed: Previous studies have shown promising results in understanding heart remodeling in related conditions, but this specific approach is novel.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Valdez-Jasso, Daniela — University of California, San Diego
- Study coordinator: Valdez-Jasso, Daniela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.