Understanding heart changes in patients with heart failure and preserved ejection fraction.
Myocardial Plasticity in Heart Failure with Preserved Ejection Fraction (HFpEF)
['FUNDING_OTHER'] · VETERANS HEALTH ADMINISTRATION · NIH-11101282
This study is looking at how heart failure with preserved ejection fraction (HFpEF) changes the heart's structure and function, especially focusing on tiny molecules that might help us understand how patients respond to exercise and how their condition might change over time, with the goal of finding better ways to detect and treat HFpEF.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS HEALTH ADMINISTRATION (nih funded) |
| Locations | 1 site (COLUMBIA, UNITED STATES) |
| Trial ID | NIH-11101282 on ClinicalTrials.gov |
What this research studies
This research investigates how heart failure with preserved ejection fraction (HFpEF) affects the heart's structure and function, particularly focusing on changes in the extracellular matrix and the role of specific microRNAs. By using a large animal model, the study aims to identify molecular markers that can predict how patients respond to exercise and how their condition progresses. The findings could lead to new tools for early detection and potential therapies for patients suffering from HFpEF.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure with preserved ejection fraction, particularly those experiencing symptoms related to left ventricular pressure overload.
Not a fit: Patients with heart failure that does not involve preserved ejection fraction or those with other unrelated cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients with heart failure and preserved ejection fraction.
How similar studies have performed: Previous research has shown promise in using microRNA profiling to understand heart failure mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
COLUMBIA, UNITED STATES
- VETERANS HEALTH ADMINISTRATION — COLUMBIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SPINALE, FRANCIS G — VETERANS HEALTH ADMINISTRATION
- Study coordinator: SPINALE, FRANCIS G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.