Understanding heart aging and its effects on heart function
Official title: Senescence Cardiomyopathy
Funded at Rutgers Biomedical and Health Sciences · NIH-11122066 · Data updated 2026-11-12
This study is looking at how getting older affects heart cells and how that can lead to heart problems, with the goal of finding ways to help improve heart health in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | May 1, 2025 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $631,261 |
| NIH project number | 1R01HL179656-01 |
| Project ID | NIH-11122066 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing heart-related issues or those at risk of heart disease due to aging.
✕Less likely to help
Patients who are younger and do not have any heart conditions or risk factors related to aging may not benefit from this research.
What this research studies
This research investigates how aging affects heart cells, particularly focusing on a process called cellular senescence, which leads to heart dysfunction. The study aims to explore the mechanisms behind decreased cellular quality control in aging hearts and how this impacts overall heart health. By examining the role of autophagy and a specific type of it called mitophagy, the research seeks to uncover ways to improve heart function in older individuals. Patients may be involved in understanding how these processes affect their heart health and potential treatments.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating heart disease in older adults.
How similar studies have gone: Previous research has shown promising results in understanding cellular aging and its impact on heart health, indicating that this approach has potential for significant findings.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Sadoshima, Junichi — Rutgers Biomedical and Health Sciences
- Study coordinator: Sadoshima, Junichi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.