Understanding Hearing Issues in Autism and Their Connection to Brain and Immune System
Autism Spectrum Disorders and Auditory System Deficits: Role of Neuronal and Immune System Dysfunction
['FUNDING_R01'] · MEDICAL UNIVERSITY OF SOUTH CAROLINA · NIH-11168836
This project explores how hearing problems in children with autism spectrum disorders might be linked to brain and immune system changes, affecting their communication and language.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL UNIVERSITY OF SOUTH CAROLINA (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-11168836 on ClinicalTrials.gov |
What this research studies
This research aims to understand how hearing difficulties in people with autism spectrum disorders (ASD) might contribute to core ASD symptoms like communication challenges. Researchers believe that problems in the peripheral auditory system, such as the auditory nerve, could lead to changes in the brain, including increased sensitivity to sound. They are using a mouse model that mimics a human genetic condition linked to ASD to uncover the exact ways these hearing and brain issues are connected. This work will help us learn more about the underlying causes of ASD-related behaviors and how they develop.
Who could benefit from this research
Good fit: This foundational research focuses on understanding the biological mechanisms of ASD and auditory deficits, so it does not directly involve patient participation at this stage.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not find direct benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify and address hearing-related challenges in individuals with autism spectrum disorders, potentially improving communication and language development.
How similar studies have performed: While the specific genetic mouse model is being used to explore novel mechanistic links, previous research has suggested a connection between auditory system deficits and ASD symptoms.
Where this research is happening
CHARLESTON, UNITED STATES
- MEDICAL UNIVERSITY OF SOUTH CAROLINA — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LANG, HAINAN — MEDICAL UNIVERSITY OF SOUTH CAROLINA
- Study coordinator: LANG, HAINAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.