Understanding health outcomes in children with Down syndrome in Texas
Down Syndrome Early Childhood Omics, Deep Phenotyping, and Epidemiology in Texas: DECODE IT Cohort
This study is looking at the health of children with Down syndrome to learn more about their unique challenges, like birth defects and other health issues, and aims to include a diverse group of kids to help improve care and support for everyone.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10999683 on NIH RePORTER |
What this research studies
This research focuses on children with Down syndrome (DS) to better understand their health outcomes, including structural birth defects, increased risk of acute leukemia, and neurodevelopmental disorders. By utilizing the Texas Birth Defects Registry, the study aims to gather comprehensive data on the variability of these health issues among children with DS. The approach includes deep phenotyping and omics analysis to identify biological markers and improve health supervision guidelines. The goal is to include underrepresented minorities in this research to ensure diverse representation and better health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with Down syndrome, particularly those from diverse backgrounds.
Not a fit: Patients without a diagnosis of Down syndrome or those outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved health supervision and intervention strategies for children with Down syndrome.
How similar studies have performed: Previous research has shown success in utilizing population-based registries to improve health outcomes for children with genetic conditions, making this approach promising.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Lupo, Philip — Baylor College of Medicine
- Study coordinator: Lupo, Philip
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.