Understanding health issues after surgery for aorta narrowing
Mechanisms of morbidity after correcting aortic coarctations of varying severity
This study is looking at how kids and teens who have surgery for a narrowed aorta might face health issues later on, especially with blood pressure, and aims to find better ways to care for them as they grow up.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11083073 on NIH RePORTER |
What this research studies
This research investigates the long-term health problems that can occur in children and adolescents after surgery to correct aortic coarctation, a condition where the aorta is narrowed. The study aims to identify how changes in blood pressure and aortic structure after surgery contribute to complications like hypertension. By analyzing patient data and developing new treatment guidelines, the research seeks to improve care for those affected by this condition. Patients will be monitored over time to assess their health outcomes and refine treatment approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents aged 0-20 who have undergone surgery for aortic coarctation.
Not a fit: Patients who have not had surgery for aortic coarctation or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies that reduce the risk of hypertension and other complications in patients who have undergone surgery for aortic coarctation.
How similar studies have performed: Previous research has shown that personalized treatment approaches can improve outcomes for patients with congenital heart defects, suggesting potential success for this study's methods.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Ladisa, John Frank — Medical College of Wisconsin
- Study coordinator: Ladisa, John Frank
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.