Understanding head volume changes in children with craniosynostosis before and after surgery
Official title: Data-driven quantification and prediction of pre-surgical local head volume distributions and post-surgical development in patients with craniosynostosis
Funded at University of Colorado Denver · NIH-11037962 · Data updated 2026-11-12
This study is looking at how to better understand and predict changes in head size for kids with craniosynostosis before and after they have surgery, so we can improve their treatment and help them grow better in the long run.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | March 1, 2023 |
| Project end | February 28, 2028 |
| Funding year | 2025 |
| Award (this year) | $399,545 |
| NIH project number | 5R01DE032681-03 |
| Project ID | NIH-11037962 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years diagnosed with craniosynostosis who are scheduled for surgical intervention.
✕Less likely to help
Patients who are older than 11 years or those who do not have craniosynostosis may not benefit from this research.
What this research studies
This research investigates how to better quantify and predict the changes in head volume for children with craniosynostosis before and after surgical treatment. By utilizing advanced imaging techniques and data-driven models, the study aims to identify the specific volume needs of patients during treatment and how their cranial growth is affected post-surgery. The goal is to develop personalized methods for evaluating long-term outcomes, which could lead to improved surgical techniques and reduced need for additional surgeries. This research focuses on children aged 0-11 years and aims to address the variability in surgical outcomes across different institutions.
Why it matters
Potential benefit: If successful, this research could lead to more effective surgical treatments and better long-term outcomes for children with craniosynostosis.
How similar studies have gone: While there have been advancements in imaging and quantifying cranial anomalies, this specific approach to predicting post-surgical growth in craniosynostosis is relatively novel and has not been extensively tested.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Porras Perez, Antonio Reyes — University of Colorado Denver
- Study coordinator: Porras Perez, Antonio Reyes
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.