Understanding gut issues in individuals with Down syndrome
Gastrointestinal Dysfunction in Down Syndrome
This study is looking at how the gut works in people with Down syndrome, using mice that have a similar condition, to find out why their intestines move more slowly and how we can help improve their digestive health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10791239 on NIH RePORTER |
What this research studies
This research investigates gastrointestinal dysfunction in individuals with Down syndrome, focusing on how the enteric nervous system and smooth muscle cells interact to control gut motility. By using a mouse model that mimics Trisomy 21, the study aims to uncover the mechanisms behind reduced colonic motility observed in these individuals. The researchers will explore the role of ionic conductances and oxidative stress in affecting gut function, which could lead to better understanding and management of gastrointestinal issues in patients with Down syndrome.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Down syndrome, particularly those experiencing gastrointestinal issues.
Not a fit: Patients without Down syndrome or those not experiencing gastrointestinal dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for gastrointestinal dysfunction in individuals with Down syndrome, enhancing their quality of life.
How similar studies have performed: Previous research has shown that understanding the enteric nervous system can lead to significant insights into gastrointestinal disorders, suggesting potential for success in this area.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Akbarali, Hamid I — Virginia Commonwealth University
- Study coordinator: Akbarali, Hamid I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.