Understanding gut issues in individuals with Down syndrome
Defining the Role of Enteric Nervous System Dysfunction in Gastrointestinal Motor and Sensory Abnormalities in Down Syndrome
This study is looking at how problems in the gut's nervous system might cause tummy troubles, like constipation, in people with Down syndrome, and it hopes to find ways to help manage these issues better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10655819 on NIH RePORTER |
What this research studies
This research investigates how dysfunction in the enteric nervous system may contribute to gastrointestinal problems commonly seen in individuals with Down syndrome. By examining the molecular mechanisms behind these issues, the study aims to clarify how damage to the enteric nervous system leads to conditions like chronic constipation and other motility disorders. The research utilizes a mouse model to explore these connections, which could ultimately inform better clinical management for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Down syndrome who experience gastrointestinal abnormalities.
Not a fit: Patients without Down syndrome or those who do not have gastrointestinal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for gastrointestinal disorders in individuals with Down syndrome.
How similar studies have performed: Previous research has indicated that enteric nervous system dysfunction is linked to gastrointestinal issues, suggesting that this approach may yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Belkind-Gerson, Jaime — University of Colorado Denver
- Study coordinator: Belkind-Gerson, Jaime
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.