Understanding Gut Immune Responses to Typhoid and Shigella
Imaging Mass Cytometry Core
This research aims to understand how our gut immune system responds to serious infections like typhoid and shigella, which are common global health concerns.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11173625 on NIH RePORTER |
What this research studies
This project focuses on uncovering the specific ways our immune system in the gut reacts to human-specific infections such as typhoid and shigella. We want to understand why current vaccines have limitations and how to better protect people from these diseases. Researchers will closely examine different immune cells, like T cells and B cells, to see how they change after vaccination or exposure to these pathogens. By studying these cells at a molecular level and how they are organized within gut tissue, we hope to gain insights that can lead to more effective prevention and treatment strategies.
Who could benefit from this research
Good fit: This research is relevant for individuals affected by or at risk for S. typhi and Shigella infections, particularly those who might participate in future vaccine or pathogen challenge studies.
Not a fit: Patients who do not have or are not at risk for typhoid or shigella infections would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to improved vaccines and better ways to protect people from serious gut infections like typhoid and shigella.
How similar studies have performed: This project builds upon the research team's extensive experience and established clinical infrastructure for studying immune responses to these enteric pathogens.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Ho, Won Jin — University of Maryland Baltimore
- Study coordinator: Ho, Won Jin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.