Understanding Gut Health, Brain Blood Flow, and Memory in Alzheimer's
Gut Immunity, Neurovascular Dysregulation and Cognitive Impairment
This work explores how gut health and blood vessel function in the brain might contribute to memory problems in Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11160712 on NIH RePORTER |
What this research studies
Alzheimer's disease and related dementias cause memory loss and thinking problems, and currently, there are no cures. We know that inflammation and issues with blood vessels in the brain play a big role in how these diseases progress. This project looks at how the immune system in your gut might talk to your brain's blood vessels and immune cells, potentially affecting memory. We are particularly interested in certain immune cells and their signals that seem to be linked to memory decline and the buildup of harmful proteins in the brain.
Who could benefit from this research
Good fit: This foundational work is for patients interested in the underlying causes of Alzheimer's disease and related dementias, particularly those with cognitive impairment.
Not a fit: Patients seeking immediate treatment options or direct clinical trial participation may not find immediate benefit from this basic science investigation.
Why it matters
Potential benefit: If successful, this work could uncover new ways to prevent or treat Alzheimer's disease by targeting the gut immune system or brain blood vessel function.
How similar studies have performed: While the specific link between gut immunity, neurovascular dysfunction, and cognitive impairment is still being established, previous research has implicated neuroinflammation and gut microbiome changes in Alzheimer's disease.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Faraco, Giuseppe — Weill Medical Coll of Cornell Univ
- Study coordinator: Faraco, Giuseppe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.