Understanding gut and brain communication in Parkinson's disease
Mayo Clinic Consortium for Gut Brain Communication in Parkinson's Disease
This study is looking at how gut issues like constipation might be linked to Parkinson's disease, and it’s for people with Parkinson's who have constipation, those who don’t, and healthy individuals, to help find better ways to understand and treat the condition.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10986353 on NIH RePORTER |
What this research studies
This research investigates how gastrointestinal symptoms, particularly constipation, relate to Parkinson's disease (PD) by exploring the connections between the gut microbiome, environmental factors, and neurodegeneration. The study will involve a multi-disciplinary team analyzing brain-gut dysfunctions and disease signatures in individuals with PD who experience constipation and those who do not, as well as healthy controls. By examining these relationships, the research aims to identify biomarkers that could improve understanding and treatment of PD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Parkinson's disease, particularly those experiencing constipation.
Not a fit: Patients with Parkinson's disease who do not experience gastrointestinal symptoms may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatments for gastrointestinal symptoms in Parkinson's disease, potentially improving overall patient quality of life.
How similar studies have performed: Previous research has shown promising results in understanding the gut-brain axis in other neurological conditions, suggesting potential for success in this novel approach.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Bharucha, Adil E. — Mayo Clinic Rochester
- Study coordinator: Bharucha, Adil E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.