Understanding guanosine signaling in brain injury
Monitoring rapid guanosine signaling during ischemia
This study is looking at how a substance called guanosine acts when blood flow to the brain is cut off, which can happen during a stroke or other brain injuries, to help us understand how it might protect the brain and improve treatments in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11014360 on NIH RePORTER |
What this research studies
This research investigates how guanosine, a nucleoside purine, behaves during episodes of ischemia, which is a condition where blood flow to the brain is restricted. By developing a specialized microfluidic platform, the researchers aim to measure guanosine signaling dynamics in real-time at the site of brain injury. This approach utilizes advanced techniques to capture the changes in guanosine levels as ischemia progresses, providing insights into its potential neuroprotective roles. The findings could enhance our understanding of the brain's immediate response to damage and inform future therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an acquired brain injury, particularly those with ischemic conditions.
Not a fit: Patients with non-ischemic brain injuries or those who do not have any brain injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that harness guanosine's protective effects to improve recovery from brain injuries.
How similar studies have performed: While the specific approach of measuring guanosine dynamics during ischemia is novel, similar studies have shown promise in understanding cellular signaling in brain injuries.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Ross, Ashley E — University of Cincinnati
- Study coordinator: Ross, Ashley E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.