Understanding growth issues in brittle bone disease
Mechanism of growth deficiency in dominant forms of osteogenesis imperfecta
This study is looking at how certain gene changes in people with osteogenesis imperfecta (OI) affect the cells that help bones grow, with the hope of finding new ways to help those with growth problems caused by this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10908339 on NIH RePORTER |
What this research studies
This research investigates the underlying mechanisms of growth deficiency in osteogenesis imperfecta (OI), a genetic disorder that leads to brittle bones. The study focuses on how mutations in collagen genes affect chondrocytes, the cells responsible for bone growth, particularly in the growth plate. By using a specific mouse model with a collagen mutation, researchers aim to uncover the cellular processes that contribute to growth impairment in OI. The findings could pave the way for developing effective treatments to address growth issues in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with dominant forms of osteogenesis imperfecta, particularly those experiencing growth deficiencies.
Not a fit: Patients with non-dominant forms of osteogenesis imperfecta or those without growth deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve growth and overall quality of life for patients with osteogenesis imperfecta.
How similar studies have performed: Previous research has shown promise in understanding the cellular mechanisms of osteogenesis imperfecta, but this specific focus on growth deficiency is relatively novel.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Otsuru, Satoru — University of Maryland Baltimore
- Study coordinator: Otsuru, Satoru
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.