Understanding Glutathione, Brain Energy, and Inflammation in Alzheimer's Disease
Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease
This work explores how a natural antioxidant called glutathione, brain energy use, and inflammation are connected in Alzheimer's disease, hoping to find new ways to help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10876305 on NIH RePORTER |
What this research studies
We know that Alzheimer's disease causes significant memory and thinking problems, and current medicines don't stop its progression. Our work focuses on how brain cells use energy, especially glucose, and how this process might go wrong in Alzheimer's. We are also looking at inflammation in the brain and how it relates to energy use and a natural protective substance called glutathione. By understanding these connections, we hope to uncover new targets for treatments that could improve thinking abilities.
Who could benefit from this research
Good fit: This foundational work is relevant to patients experiencing cognitive decline associated with Alzheimer's disease and age-related memory issues.
Not a fit: Patients with cognitive impairments not related to Alzheimer's disease or age-related decline may not directly benefit from this specific line of inquiry.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that target brain energy use, inflammation, or glutathione levels to slow or reverse cognitive decline in Alzheimer's disease.
How similar studies have performed: While the specific unifying link of oxidative stress, glutathione deficiency, and mitochondrial dysfunction in AD is being explored, components of this approach, such as targeting oxidative stress, have been investigated in other contexts.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Sekhar, Rajagopal Viswanath — Baylor College of Medicine
- Study coordinator: Sekhar, Rajagopal Viswanath
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.