Understanding Glaucoma with Advanced Tools
Multiomic Framework for Glaucoma
This project looks at blood samples and genetic information from people with and without glaucoma to better understand what causes this eye condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11187212 on NIH RePORTER |
What this research studies
Glaucoma is a serious eye disease that can lead to permanent vision loss. Our team is examining proteins and other small molecules found in blood plasma, along with genetic factors, to uncover how they contribute to glaucoma. We are also using artificial intelligence to identify different types of glaucoma based on patterns of vision loss. This work involves analyzing existing samples and data from large health studies to gain a deeper understanding of the disease's origins.
Who could benefit from this research
Good fit: This research uses existing blood samples and data from large health studies, so direct patient recruitment for new samples is not part of this specific grant.
Not a fit: Patients not affected by primary open-angle glaucoma or those not part of the Nurses' Health Study or Health Professionals Follow-up Study cohorts would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to earlier detection and more personalized treatments for glaucoma, potentially preventing vision loss for many patients.
How similar studies have performed: While individual components like proteomic and metabolomic analyses have been used in other diseases, combining them with genetic data and AI for glaucoma subtypes in this multiomic framework is a cutting-edge approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Pasquale, Louis Robert — Icahn School of Medicine at Mount Sinai
- Study coordinator: Pasquale, Louis Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.