Understanding genetics to predict kidney disease and hypertension risks
Official title: Genetics of CKD and Hypertension-Risk Prediction and Drug Response in the MVP
Funded at Veterans Health Administration · NIH-10863818 · Data updated 2026-11-12
This study is looking at how your genes might help doctors predict your risk of chronic kidney disease and high blood pressure, so they can offer you personalized care sooner and help slow down any problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | October 1, 2024 |
| Project end | September 30, 2028 |
| Funding year | 2024 |
| NIH project number | 5I01CX001897-05 |
| Project ID | NIH-10863818 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are at risk for or currently have chronic kidney disease or hypertension.
✕Less likely to help
Patients with no genetic predisposition to chronic kidney disease or hypertension may not benefit from this research.
What this research studies
This research investigates how genetic factors can help predict the risk of chronic kidney disease (CKD) and hypertension in patients. By generating Genetic Risk Scores (GRS) based on extensive genetic data, the study aims to improve the prediction of CKD progression and treatment responses. Patients with a higher genetic risk may receive tailored interventions earlier, potentially slowing disease progression. The research will also explore the use of polygenic risk scores to enhance prediction accuracy further.
Why it matters
Potential benefit: If successful, this research could lead to more effective prevention and treatment strategies for chronic kidney disease and hypertension, ultimately improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using genetic risk scores for predicting various health conditions, indicating that this approach may be effective.
Where this research is happening
-
Veterans Health Administration
Nashville, United States Active
Researchers
- Principal investigator: Hung, Adriana — Veterans Health Administration
- Study coordinator: Hung, Adriana
Related research
Other NIH-funded projects on the same topics.
-
HEARTS hypertension and diabetes care in Guatemala
This grant tests how well the HEARTS primary care model works in Guatemala to improve blood pressure and blood sugar control for patients.
-
Integrated Heart Health: A HEARTS-based approach to hypertension and diabetes in Guatemala
A study tests a team-based, stepwise care model to improve blood pressure and blood sugar control for people with both hypertension and diabetes in Guatemala.
-
Coaching and Navigation by Community Health Workers via Telehealth for High-Risk Hypertension
A program using telehealth and community health workers to help adults with severe hypertension connect to primary care and follow practical, heart-healthy lifestyle tips.
-
Community Health Worker–Led Hypertension Prevention and Control in Nepal
A community health worker–driven approach in Nepal aims to prevent and control high blood pressure among adults by bringing education and care directly to communities and homes.
-
Community health worker-led hypertension prevention and control in Nepal
A community health worker–led program in Nepal aims to help adults prevent and better control high blood pressure through home visits, education, and ongoing support.
-
Noninvasive portal pressure estimation using ultrasound-based subharmonic signals
A noninvasive ultrasound method to estimate portal vein pressure in adults with cirrhosis to help manage varices and ascites.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.