Understanding genetic variations linked to neuropsychiatric disorders
Scalable tool and comprehensive maps to interpret structural variation across the neuropsychiatric spectrum
This study is looking at how changes in our DNA might be linked to conditions like autism and bipolar disorder, and it aims to create helpful maps to understand these connections better, so that we can improve treatments for people affected by these disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11118867 on NIH RePORTER |
What this research studies
This research investigates how structural variations in DNA contribute to neuropsychiatric disorders such as autism and bipolar disorder. By analyzing large-scale genetic data, the study aims to create comprehensive maps that illustrate the impact of these variations across different populations. The approach involves developing new tools to measure the effects of DNA changes on mental health, which could lead to better understanding and treatment options for affected individuals. Patients may be involved in providing genetic samples to help build a more complete picture of these disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals diagnosed with autism spectrum disorder or bipolar disorder, as well as their family members.
Not a fit: Patients with neuropsychiatric disorders not represented in the study, or those without a genetic component to their condition, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for neuropsychiatric disorders.
How similar studies have performed: Previous research has shown success in using genetic mapping to understand other complex disorders, indicating a promising approach for this study.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Talkowski, Michael E — Broad Institute, INC.
- Study coordinator: Talkowski, Michael E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.