Understanding genetic variations in human tissues
Official title: WashU-VAI Somatic Mosaicism across Human Tissues (SMaHT) Program Genome Characterization Center
Funded at Washington University · NIH-11083076 · Data updated 2026-11-12
This study is looking at how differences in our genes can affect our health and diseases, and it aims to create a detailed map of these differences to help find better ways to diagnose and treat conditions, which could benefit patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $2,999,999 |
| NIH project number | 5UM1DA058219-03 |
| Project ID | NIH-11083076 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions that may be influenced by somatic genetic variations.
✕Less likely to help
Patients with purely hereditary conditions that do not involve somatic mutations may not benefit from this research.
What this research studies
This research focuses on exploring how genetic variations in somatic tissues can influence human health and disease. The project aims to create a comprehensive catalog of these variations by generating high-quality genomic DNA and RNA sequencing data. Patients may benefit from this research as it seeks to uncover new biological processes that could lead to improved diagnostics and treatments. The research will involve collaboration with various institutions to ensure efficient data management and analysis.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding diseases linked to genetic variations, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promise in understanding somatic mosaicism, indicating that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Wang, Ting — Washington University
- Study coordinator: Wang, Ting
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.