Understanding genetic variations in Alzheimer's disease
Characterizing complex structural variation in Alzheimer's disease
This study is looking at the genetic changes that might play a role in late-onset Alzheimer's disease, hoping to find new clues that could help us understand the disease better and lead to improved treatments for those affected.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10875750 on NIH RePORTER |
What this research studies
This research investigates the complex genetic factors associated with late-onset Alzheimer's disease (LOAD), focusing on structural variants (SVs) that may contribute to the disease's heritability. By analyzing a large dataset of whole genome sequences from diverse individuals, the study aims to identify novel genetic variations linked to LOAD. This could lead to a better understanding of the biological mechanisms behind the disease and potentially uncover new targets for treatment and diagnosis.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with late-onset Alzheimer's disease or those at risk due to family history.
Not a fit: Patients with early-onset Alzheimer's disease or those without a genetic predisposition to the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options and diagnostic tools for Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Vardarajan, Badri N — Columbia University Health Sciences
- Study coordinator: Vardarajan, Badri N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.