Understanding genetic variants in children using large datasets
GENOMIC INDEXING OF COMMON FUND DATASETS
This study is working to help doctors and researchers better understand how certain genetic changes that don’t make proteins can affect children's health, so they can make smarter choices about genetic testing and personalized treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11087940 on NIH RePORTER |
What this research studies
This research focuses on improving the interpretation of genetic variants, particularly those that do not code for proteins, which are increasingly revealed by whole genome sequencing (WGS). By utilizing large datasets generated from various Common Fund projects, the research aims to provide better insights into how these non-coding variants affect gene regulation and function. The project will enhance the accessibility and interoperability of variant information, making it easier for researchers and clinicians to understand the implications of genetic variations in children. This could lead to more informed decisions regarding genetic testing and personalized medicine.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who may have genetic variants of unknown significance.
Not a fit: Patients with well-characterized genetic conditions that do not involve non-coding variants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of genetic conditions in children.
How similar studies have performed: Previous research has shown promise in utilizing large genomic datasets to interpret genetic variants, indicating that this approach has potential for success.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Milosavljevic, Aleksandar — Baylor College of Medicine
- Study coordinator: Milosavljevic, Aleksandar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.