Understanding genetic risks for Alzheimer's disease in African and African American populations
Official title: Characterizing the Genetic Risk for Alzheimer Disease in African and Admixed African-American Ancestries
Funded at University of Miami School of Medicine · NIH-10982115 · Data updated 2026-11-12
This study is looking at how genetics may affect Alzheimer's disease in people of African and African American backgrounds, aiming to find unique risk factors and improve prevention strategies, while also tracking participants' cognitive health over time.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 30, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $4,050,927 |
| NIH project number | 1U01AG084545-01A1 |
| Project ID | NIH-10982115 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals of African or African American ancestry, particularly those with a family history of Alzheimer's disease or mild cognitive impairment.
✕Less likely to help
Patients who do not have African or African American ancestry may not benefit from the findings of this research.
What this research studies
This research investigates the genetic factors contributing to Alzheimer's disease (AD) specifically in individuals of African and African American ancestry. By analyzing whole genome sequencing and biomarkers from a diverse cohort, the study aims to identify unique genetic risk patterns that differ from those found in predominantly European ancestry populations. Participants will undergo longitudinal follow-ups to assess cognitive health over time, providing valuable insights into the progression of AD in these communities. The research seeks to enhance the understanding of AD risk and improve prevention strategies tailored to diverse populations.
Why it matters
Potential benefit: If successful, this research could lead to more effective prevention and treatment strategies for Alzheimer's disease tailored to African and African American individuals.
How similar studies have gone: Previous research has shown that genetic studies focusing on diverse populations can reveal significant differences in disease risk, indicating that this approach has the potential for meaningful insights.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Griswold, Anthony John — University of Miami School of Medicine
- Study coordinator: Griswold, Anthony John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.