Understanding genetic risk for diseases in people from different backgrounds
Polygenic Risk of Disease in Populations of Diverse Ancestry
This study is looking for people from different backgrounds to help create a tool that can better predict the risk of common diseases like heart disease based on genetics, so everyone can get fairer health care and support.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10894636 on NIH RePORTER |
What this research studies
This research focuses on developing polygenic risk scores (PRSs) that can accurately assess the risk of common diseases, such as coronary heart disease, in individuals from diverse ancestry groups. By analyzing genomic and health data, the study aims to create more equitable risk assessments that can be used in clinical settings. The goal is to ensure that genomic medicine benefits all populations, reducing health disparities. Participants may contribute to the understanding of how genetic factors influence disease risk across different ethnic backgrounds.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from diverse ancestry groups who are at risk for coronary heart disease and related conditions.
Not a fit: Patients with rare genetic disorders or those not at risk for common diseases like coronary heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective prevention strategies for common diseases based on genetic risk.
How similar studies have performed: Previous research has shown promise in developing polygenic risk scores for specific populations, but this approach aims to expand those findings to a broader range of diverse ancestry groups.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Kullo, Iftikhar J — Mayo Clinic Rochester
- Study coordinator: Kullo, Iftikhar J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.