Understanding Genetic Risk for Diabetes and Other Health Conditions
Comprehensive Polygenic Risk Profiling Across Multiple Health Outcomes (CARDINAL)
This project aims to better understand how our genes contribute to the risk of developing conditions like type 2 diabetes, high blood pressure, and certain cancers by looking at genetic information from many adults.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11066486 on NIH RePORTER |
What this research studies
We are combining genetic information with health records and lab results from over 50,000 adults who are part of existing US health initiatives. Our goal is to create more accurate genetic risk scores that work well for diverse groups of people. By using advanced computer methods, we can better predict who might be at higher risk for conditions like type 2 diabetes, certain cancers, and high blood pressure. This helps us understand how genetics and lifestyle factors work together to influence health.
Who could benefit from this research
Good fit: This project uses existing health data from adults aged 21 and older, particularly those of African ancestry, who have been enrolled in US research initiatives.
Not a fit: Patients not included in the existing research initiatives or those outside the specified age range may not directly benefit from this particular data analysis.
Why it matters
Potential benefit: If successful, this work could lead to more personalized risk assessments, helping individuals and their doctors make more informed decisions about health screening and prevention strategies.
How similar studies have performed: While polygenic risk scores have shown promise in other studies, this project aims to refine and improve their accuracy, especially for diverse populations where current scores may be less precise.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Adebamowo, Sally Nneoma — University of Maryland Baltimore
- Study coordinator: Adebamowo, Sally Nneoma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.