Understanding genetic risk for cardiovascular disease in diverse populations
Polygenic Risk Scores for Diverse Populations - Bridging Research and Clinical Care
This study is looking at how we can better use genetic information to understand heart disease risk in people from different racial and ethnic backgrounds, so that everyone can get more personalized and effective care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10673171 on NIH RePORTER |
What this research studies
This research investigates how polygenic risk scores (PRS) can be effectively used to assess cardiovascular disease (CVD) risk in racially and ethnically diverse populations. It aims to develop methods that accurately estimate and interpret these scores, addressing the limitations of existing models that primarily focus on individuals of European ancestry. By integrating environmental and lifestyle factors with genetic data, the research seeks to enhance the clinical utility of PRS in predicting CVD risk across different ethnic groups. This approach is crucial for reducing health disparities and improving personalized care for all populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from racially and ethnically diverse backgrounds who are at risk for cardiovascular disease.
Not a fit: Patients who are not part of racially or ethnically diverse populations may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate risk assessments for cardiovascular disease, allowing for tailored prevention and treatment strategies for diverse populations.
How similar studies have performed: Previous research has shown that polygenic risk scores can be effective in predicting disease risk, but this study aims to adapt these methods for broader applicability in diverse populations, making it a novel approach.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Kooperberg, Charles L — Fred Hutchinson Cancer Center
- Study coordinator: Kooperberg, Charles L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.