Understanding genetic risk for Alzheimer's disease in Hispanic and Latinx populations
Official title: Polygenic Risk Scores for Alzheimer's Disease in Hispanic/Latinx Populations
Funded at Columbia University Health Sciences · NIH-10662781 · Data updated 2026-11-12
This study is looking at how genes might affect the risk of developing late-onset Alzheimer's disease in Hispanic and Latinx people, aiming to create a better way to understand individual risk by using a mix of common and rare genetic information.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 15, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,868,557 |
| NIH project number | 1RF1AG082009-01A1 |
| Project ID | NIH-10662781 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Hispanic and Latinx individuals who may be at risk for late-onset Alzheimer's disease.
✕Less likely to help
Patients who do not identify as Hispanic or Latinx or those who do not have a family history of Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the genetic factors contributing to late-onset Alzheimer's disease (LOAD) specifically in Hispanic and Latinx populations. By utilizing polygenic risk scores (PRS), the study aims to create a comprehensive genetic risk profile that incorporates both common and rare genetic variants. The research will leverage large cohorts from Columbia University to develop ancestry-specific PRS, which could enhance the accuracy of disease prediction and patient risk stratification. This approach is innovative as it addresses the gap in existing research that primarily focuses on European-descended populations.
Why it matters
Potential benefit: If successful, this research could lead to more accurate risk assessments for Alzheimer's disease in Hispanic and Latinx individuals, potentially guiding early interventions and personalized treatment strategies.
How similar studies have gone: Previous research has shown success in developing polygenic risk scores for other populations, but this approach is novel for Hispanic and Latinx groups.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Tosto, Giuseppe — Columbia University Health Sciences
- Study coordinator: Tosto, Giuseppe
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.