Understanding genetic risk factors for frontotemporal dementia
Core D: Data
This study is looking into the genetic causes of frontotemporal dementia, especially two types called Progressive Supranuclear Palsy and FTD-Tau, to help find better ways to diagnose and treat these conditions for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10906049 on NIH RePORTER |
What this research studies
This research focuses on exploring the genetic mechanisms behind frontotemporal dementia, particularly Progressive Supranuclear Palsy and FTD-Tau, which are linked to mutations in the MAPT gene. By utilizing a genomic and multi-omic approach, the project aims to generate and analyze a vast array of data, including transcriptomics and proteomics from brain tissues. The Data Core will facilitate the storage, analysis, and sharing of this data to enhance scientific discoveries and understanding of these conditions. Patients may benefit from insights that could lead to improved diagnostics and treatments for frontotemporal dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with frontotemporal dementia or those with a family history of related genetic mutations.
Not a fit: Patients with other forms of dementia not related to frontotemporal degeneration may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential new treatments for patients with frontotemporal dementia.
How similar studies have performed: Previous research has shown promise in understanding genetic factors in dementia, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Chang, Timothy S — Icahn School of Medicine at Mount Sinai
- Study coordinator: Chang, Timothy S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.