Understanding genetic risk and early development in autism
Core B: Statistical and Computational Analysis Core
This work uses genetic information, caregiver reports, and early developmental checks to find genes and patterns that signal autism risk in young children.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11176972 on NIH RePORTER |
What this research studies
At Columbia, specialists combine genetic testing, caregiver surveys, and repeated developmental measures for young children who have identified genetic changes linked to autism. The core team applies advanced statistics, bioinformatics, and reproducible data methods to search for risk genes and build genomic risk scores across common and rare variants. They link genetic signals to children’s developmental trajectories and analyze caregiver experiences and decision-making over time. All data are managed securely and processed to produce reliable results that can inform future screening and family support.
Who could benefit from this research
Good fit: Children aged 0–11 who have a known genetic change associated with autism, along with their caregivers, are the ideal candidates for participation.
Not a fit: Adults, older children, or people without identified genetic risk (or those unable to provide genetic samples or participate in follow-up) are unlikely to receive direct benefit from this specific work.
Why it matters
Potential benefit: Could help identify genetic markers and early behavioral patterns that lead to earlier, more personalized support for children and families affected by autism.
How similar studies have performed: Prior autism cohort studies have found genetic links and early behavioral markers, though combining genome-wide risk scores with caregiver decision data is relatively new.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Wall, Melanie M — Columbia University Health Sciences
- Study coordinator: Wall, Melanie M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.