Understanding genetic risk and brain cell changes in Alzheimer's disease
Contribution of AD genetic risk and microglial BIN1 to tauopathy
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11194359
This research explores how specific genetic factors and brain cells called microglia contribute to Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11194359 on ClinicalTrials.gov |
What this research studies
Alzheimer's disease is a common cause of memory loss, and current treatments are limited. We know that certain genetic differences can increase the risk of developing Alzheimer's, but we don't fully understand how these genes work in specific brain cells. This project focuses on a gene called BIN1 and its role in microglia, which are immune cells in the brain. We believe that changes in this gene, especially within microglia, might be a key factor in how Alzheimer's disease develops. Our goal is to uncover these detailed mechanisms to help find new ways to prevent or treat the disease.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but its findings could eventually benefit individuals at risk for or living with Alzheimer's disease.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not receive benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of Alzheimer's disease, potentially identifying new targets for future treatments or prevention strategies.
How similar studies have performed: While the specific mechanisms of BIN1 in microglia are still being uncovered, other genetic studies have successfully identified risk factors for Alzheimer's disease.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COUFAL, NICOLE GABRIELE — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: COUFAL, NICOLE GABRIELE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer disease prevention, Alzheimer syndrome, Alzheimer's Disease