Understanding genetic networks to improve cancer treatment
Project 2: Functional Genetic Networks for Systems-Guided Precision Medicine
This study is looking at how genes affect how well cancer treatments work, especially for breast cancer, so that doctors can create more personalized therapies that fit each patient's unique genetic makeup.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10911942 on NIH RePORTER |
What this research studies
This research investigates how genetic networks influence the effectiveness of cancer therapies, particularly in breast cancer and other related cancers. By utilizing CRISPR/Cas9 technology, the team will conduct a series of experiments to identify key genetic interactions that can inform personalized treatment strategies. The goal is to create a detailed map of genetic factors that affect tumor behavior and response to therapies, ultimately leading to more effective precision medicine approaches for patients. Patients may benefit from therapies that are specifically tailored to their unique genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer or related cancers who are seeking personalized treatment options.
Not a fit: Patients with non-cancerous conditions or those whose tumors do not involve the genetic pathways being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized cancer treatments based on individual genetic makeup.
How similar studies have performed: Previous research using CRISPR technology has shown promise in identifying genetic interactions and improving treatment outcomes in cancer, indicating a strong potential for success in this approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Fraley, Stephanie Irene — University of California, San Francisco
- Study coordinator: Fraley, Stephanie Irene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.