Understanding genetic mutations that cause allergic diseases in children
Official title: Mechanistic elucidation of pathogenic CBM complex mutations associated with atopic disease
Funded at Henry M. Jackson Fdn for the Adv Mil/med · NIH-10881991 · Data updated 2026-11-12
This study is looking at how certain genetic changes can affect the immune system in kids with allergies and conditions like asthma and eczema, and it hopes to find new ways to help manage these issues, possibly using a substance called glutamine.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project start | July 5, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $708,492 |
| NIH project number | 5R01AI168295-02 |
| Project ID | NIH-10881991 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are children aged 0-11 years who have been diagnosed with atopic diseases such as asthma, eczema, or food allergies.
✕Less likely to help
Patients with non-allergic conditions or those outside the age range of 0-11 years may not benefit from this research.
What this research studies
This research investigates how specific genetic mutations in the CBM complex affect the immune system, particularly in children with atopic diseases like asthma and eczema. By studying the signaling processes disrupted by these mutations, researchers aim to understand how they lead to abnormal immune responses and allergic reactions. The project will also explore potential treatment strategies, including the use of glutamine, to help manage these conditions. Patients with severe allergies and immune disorders may be directly involved in this research to better understand their conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for children suffering from severe allergic diseases.
How similar studies have gone: Previous research has shown promising results in understanding immune disorders linked to genetic mutations, indicating a potential for success in this area.
Where this research is happening
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Henry M. Jackson Fdn for the Adv Mil/med
Bethesda, United States Active
Researchers
- Principal investigator: Snow, Andrew L — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Snow, Andrew L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.