Understanding genetic mutations linked to autism using 3D brain models
Modeling ASD-linked genetic mutations in 3D human brain organoids
This study is looking at how certain genetic changes linked to autism spectrum disorder (ASD) affect brain development by using tiny, lab-grown brain models, helping us understand how these changes might lead to differences in how the brain grows and connects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10980590 on NIH RePORTER |
What this research studies
This research investigates how specific genetic mutations associated with autism spectrum disorder (ASD) affect brain development by using advanced 3D human brain organoids. These organoids mimic the human brain's structure and function, allowing researchers to observe how mutations in genes like CHD8 influence the growth and connectivity of neurons. By studying these organoids, the research aims to uncover the underlying mechanisms of ASD and how they lead to developmental abnormalities in the brain. This approach combines genetic analysis with innovative cell culture techniques to provide insights into the neurodevelopmental processes involved in ASD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, particularly those with known genetic mutations.
Not a fit: Patients without a diagnosis of autism spectrum disorder or those whose conditions are unrelated to the genetic mutations being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential new treatments for autism spectrum disorder.
How similar studies have performed: Previous research using similar 3D brain organoid models has shown promising results in understanding neurodevelopmental disorders, indicating that this approach is both innovative and supported by prior successes.
Where this research is happening
Cambridge, United States
- Harvard University — Cambridge, United States (Active)
Researchers
- Principal investigator: Arlotta, Paola — Harvard University
- Study coordinator: Arlotta, Paola
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.