Understanding genetic mutations in breast cancer among African Americans
Project 1
This study is looking at the genetic changes linked to hereditary breast cancer in African American individuals to better understand how these changes might affect treatment and prevention, with the hope of improving care and reducing differences in health outcomes for this community.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-11034068 on NIH RePORTER |
What this research studies
This research investigates the genetic mutations associated with hereditary breast cancer, focusing specifically on African American populations. It aims to identify and classify variants of uncertain significance (VUS) that may affect cancer treatment and prevention. By utilizing advanced molecular biology techniques and aggregating epidemiological data, the study seeks to improve the understanding of how these mutations impact African Americans, who are often underrepresented in genetic research. The ultimate goal is to enhance cancer care and reduce disparities in treatment outcomes for this population.
Who could benefit from this research
Good fit: Ideal candidates for this research include African American individuals with a family history of breast cancer or those who have been identified with genetic mutations.
Not a fit: Patients who do not identify as African American or those without a family history of breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted cancer treatments and prevention strategies for African American patients.
How similar studies have performed: Previous research has shown success in reclassifying genetic variants in other populations, but this approach is novel in its specific focus on African Americans.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Purrington, Kristen S. — Wayne State University
- Study coordinator: Purrington, Kristen S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.