Understanding genetic interactions in yeast using advanced DNA techniques
Characterizing epistasis in yeast using CRISPR and chromosome synthesis
This study is looking at how different genes work together to affect traits in living things, which can help us understand why some people respond differently to diseases and treatments, and it uses advanced tools to explore these genetic interactions in yeast.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11135305 on NIH RePORTER |
What this research studies
This research investigates how genetic interactions, known as epistasis, influence variations in traits among organisms. By utilizing CRISPR technology and DNA barcoding, the team aims to identify and analyze the genetic mechanisms that lead to different effects in genetically diverse individuals. The study involves examining how these genetic variations can complicate disease prediction and treatment based on genomic data. Additionally, the researchers are developing methods to create synthetic chromosomes that can replace natural ones in yeast, which may enhance our understanding of genetic functions.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with genetic disorders or those interested in personalized medicine approaches.
Not a fit: Patients with conditions unrelated to genetic variations or those not interested in genetic research may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for predicting and treating genetic diseases in humans.
How similar studies have performed: Previous research using CRISPR and genetic analysis has shown promising results in understanding genetic interactions, indicating that this approach has potential for success.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Ehrenreich, Ian Michael — University of Southern California
- Study coordinator: Ehrenreich, Ian Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.