Understanding genetic factors that influence the risk of Type 1 diabetes in children
Official title: Identifying cell-type specific genetic control of T1D risk variants in TEDDY
Funded at University of Virginia · NIH-11019834 · Data updated 2026-11-12
This study is looking at how certain genes might influence the chances of kids developing Type 1 diabetes by examining their immune responses, and it's designed for families with newborns who are at risk for this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,547,165 |
| NIH project number | 5R01DK138367-02 |
| Project ID | NIH-11019834 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns and young children who have a genetic predisposition to Type 1 diabetes.
✕Less likely to help
Patients who are older than 11 years or those without a genetic risk for Type 1 diabetes may not benefit from this research.
What this research studies
This research investigates how specific genetic factors contribute to the risk of developing Type 1 diabetes (T1D) in children, particularly focusing on immune responses that target insulin-producing beta cells. By analyzing samples from the TEDDY study, which follows newborns at genetic risk for T1D, the researchers will use advanced single-cell sequencing technology to profile immune markers over time. This approach aims to identify how genetic variations affect immune cell behavior and the progression of autoimmunity related to T1D.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new strategies for preventing or managing Type 1 diabetes in at-risk children.
How similar studies have gone: Previous studies have successfully identified genetic risk factors for Type 1 diabetes, making this research a continuation of established findings in the field.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Onengut, Suna — University of Virginia
- Study coordinator: Onengut, Suna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.