Understanding genetic factors that influence prostate cancer development
Official title: Germline Determinants of Prostate Cancer Evolution
Funded at University of California Los Angeles · NIH-11056737 · Data updated 2026-11-12
This study is looking at how your genes from your parents might influence the way prostate cancer develops and how aggressive it can be, with the hope of finding clues that could help doctors tailor treatments just for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $565,798 |
| NIH project number | 5R01CA270108-03 |
| Project ID | NIH-11056737 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include men of various ancestries, particularly those with a family history of prostate cancer or those diagnosed with localized prostate cancer.
✕Less likely to help
Patients with advanced metastatic prostate cancer or those without a genetic predisposition to prostate cancer may not benefit from this research.
What this research studies
This research investigates how genetic factors inherited from parents may affect the development and aggressiveness of prostate cancer in men. By analyzing the genetic makeup of individuals and comparing it with their cancer characteristics, the study aims to identify specific genetic markers that could predict the risk and severity of prostate cancer. The research will utilize advanced genomic techniques and data analysis to uncover these relationships, potentially leading to more personalized treatment approaches for patients. The findings could help refine current screening and treatment strategies for prostate cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and treatment strategies for prostate cancer, ultimately enhancing patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding genetic influences on prostate cancer, indicating that this approach has potential for significant advancements.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Boutros, Paul Christopher — University of California Los Angeles
- Study coordinator: Boutros, Paul Christopher
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.