Understanding genetic factors that influence inflammatory bowel diseases
Official title: Genetic variants guiding pathogenicity of colitogenic T cells
Funded at Benaroya Research Inst at Virginia Mason · NIH-10991186 · Data updated 2026-11-12
This study is looking at how certain genes might change the way immune cells behave in people with inflammatory bowel diseases (IBD), which could help us understand the condition better and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $498,064 |
| NIH project number | 1R01DK140972-01 |
| Project ID | NIH-10991186 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel diseases, such as Crohn's disease or ulcerative colitis.
✕Less likely to help
Patients without inflammatory bowel diseases or those with other unrelated conditions may not benefit from this research.
What this research studies
This research investigates how specific genetic variants affect the behavior of immune cells, particularly pathogenic Th17 cells, in individuals with inflammatory bowel diseases (IBDs). By analyzing non-coding regions of the genome, the study aims to identify genetic factors that contribute to the risk and progression of IBD. The researchers will use advanced techniques like massively parallel reporter assays to assess how these genetic variants influence the function of Th17 cells, which play a critical role in inflammation. This approach could lead to a better understanding of the underlying mechanisms of IBD and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for patients with inflammatory bowel diseases.
How similar studies have gone: Previous research has shown promise in understanding genetic influences on autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Benaroya Research Inst at Virginia Mason
Seattle, United States Active
Researchers
- Principal investigator: Ray, John Philip — Benaroya Research Inst at Virginia Mason
- Study coordinator: Ray, John Philip
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.