Understanding genetic factors that influence alcohol use disorders
Distinguishing preexistent and induced epigenetic risk for alcohol use disorders
This study is looking at how our genes and changes in our DNA might influence drinking habits and alcohol use disorders, using a year-long observation of nonhuman primates to help us understand how alcohol affects the brain, which could lead to better treatments for people struggling with alcohol issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10624387 on NIH RePORTER |
What this research studies
This research investigates the genetic and epigenetic factors that contribute to alcohol use disorders (AUD) by examining DNA methylation patterns in the brain. Using a nonhuman primate model, the study measures voluntary alcohol consumption over a year to classify drinking behaviors and analyze brain tissue samples. The goal is to differentiate between preexisting genetic risks for alcohol dependence and changes induced by alcohol consumption, which could lead to new treatment strategies for AUD. By understanding these mechanisms, the research aims to provide insights into how alcohol affects the brain at a molecular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol use disorders or those at risk for developing such conditions.
Not a fit: Patients who do not consume alcohol or have no history of alcohol use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for individuals struggling with alcohol use disorders.
How similar studies have performed: Previous research has shown promising results in understanding the genetic basis of alcohol dependence, suggesting that this approach could yield valuable insights.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Cervera Juanes, Rita P — Wake Forest University Health Sciences
- Study coordinator: Cervera Juanes, Rita P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.