Understanding genetic factors that increase the risk of Parkinson's disease from pesticide exposure
Official title: Investigating Novel Genetic Variants that Confer Susceptibility to Pesticide-induced Parkinson's Disease
Funded at J. David Gladstone Institutes · NIH-11048621 · Data updated 2026-11-12
This study is looking at how some people might be more likely to get Parkinson's disease from being around pesticides, especially focusing on agricultural workers, and it aims to find out which specific genes are involved by using advanced lab techniques.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | January 17, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $728,408 |
| NIH project number | 1R01ES036325-01A1 |
| Project ID | NIH-11048621 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are agricultural workers who have been exposed to pesticides and may have a family history of Parkinson's disease.
✕Less likely to help
Patients who have not been exposed to pesticides or do not have a genetic predisposition to Parkinson's disease may not benefit from this research.
What this research studies
This research investigates how certain genetic variants may make individuals more susceptible to developing Parkinson's disease due to pesticide exposure. By analyzing data from agricultural workers, the study aims to identify specific gene variants linked to this increased risk. The researchers will use advanced techniques like whole genome sequencing and CRISPR technology to validate these genetic factors in human neuronal cultures and mouse models. This approach will help clarify the biological mechanisms behind pesticide-induced Parkinson's disease.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential prevention strategies for Parkinson's disease in individuals exposed to pesticides.
How similar studies have gone: Previous research has shown success in identifying genetic factors related to environmental exposures and diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
J. David Gladstone Institutes
San Francisco, United States Active
Researchers
- Principal investigator: Kaye, Julia Ann — J. David Gladstone Institutes
- Study coordinator: Kaye, Julia Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.