Understanding genetic factors that increase the risk of inflammatory bowel disease (IBD)
Official title: Multi-omic characterization of genetic variants in IBD risk loci
Funded at Univ of North Carolina Chapel Hill · NIH-11034091 · Data updated 2026-11-12
This study is looking at how certain genetic differences might influence inflammatory bowel disease (IBD) by examining specific parts of our DNA, which could help us better understand what causes the condition and how it affects the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | March 1, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $413,948 |
| NIH project number | 5R01DK138462-02 |
| Project ID | NIH-11034091 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with inflammatory bowel disease or those with a family history of the condition.
✕Less likely to help
Patients without a diagnosis of inflammatory bowel disease or those not genetically predisposed to the condition may not benefit from this research.
What this research studies
This research investigates the genetic variants associated with inflammatory bowel disease (IBD) by analyzing genomic loci identified through previous studies. It aims to uncover how these genetic variations affect gene regulation and contribute to the disease's development. By focusing on molecular quantitative trait loci (QTL), the research will explore the relationship between genetic variants and cellular processes, such as gene expression and alternative splicing. This approach seeks to fill gaps in understanding the mechanisms behind IBD, particularly in non-coding regions of the genome.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of IBD, potentially guiding more effective treatments and preventive strategies for patients.
How similar studies have gone: Previous research has shown success in identifying genetic variants linked to other diseases, suggesting that this approach may yield valuable insights for IBD as well.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Furey, Terrence S. — Univ of North Carolina Chapel Hill
- Study coordinator: Furey, Terrence S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.