Understanding genetic factors that contribute to pulmonary arterial hypertension
Post-GWAS Functional Genomics Analysis to Define Pathogenic Mechanisms for Pulmonary ArterialHypertension
This study is looking at how certain genes might affect the risk and severity of pulmonary arterial hypertension (PAH), which is a serious lung condition, to help find better treatments for people living with it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11177334 on NIH RePORTER |
What this research studies
This research investigates the genetic mechanisms behind pulmonary arterial hypertension (PAH), a serious condition affecting blood vessels in the lungs. By analyzing specific genetic variations identified through genome-wide association studies (GWAS), the study aims to uncover how these variations influence the risk and severity of PAH. The researchers will use advanced functional genomics techniques to explore the role of a particular genetic variant in the SOX17 gene, which is believed to be involved in the disease's development. This approach may help clarify the biological pathways that lead to PAH, potentially guiding future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with pulmonary arterial hypertension, particularly those with a genetic predisposition to the condition.
Not a fit: Patients without pulmonary arterial hypertension or those whose condition is not influenced by genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and targeted therapies for patients with pulmonary arterial hypertension.
How similar studies have performed: Previous research using similar genetic analysis approaches has shown promise in uncovering disease mechanisms, suggesting potential for success in this study.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Sun, Wei — University of California, San Diego
- Study coordinator: Sun, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.