Understanding genetic factors that cause heart rhythm problems
Official title: From variants to mechanisms for cardiac arrhythmias
Funded at Upstate Medical University · NIH-11226706 · Data updated 2026-11-12
This study is looking at how certain genes might affect the chances of having irregular heartbeats, and it's for anyone interested in understanding more about heart health and potential new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $761,182 |
| NIH project number | 7R01HL170051-03 |
| Project ID | NIH-11226706 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of cardiac arrhythmias or those who have experienced irregular heartbeats.
✕Less likely to help
Patients without any genetic predisposition to cardiac arrhythmias or those with arrhythmias caused by non-genetic factors may not benefit from this research.
What this research studies
This research investigates how specific genetic variations are linked to the risk of developing cardiac arrhythmias, which are irregular heartbeats. By using advanced techniques like CRISPR-Cas9 to modify gene expression and single nucleus RNA sequencing on human heart tissue, the researchers aim to uncover the biological mechanisms behind these genetic associations. This could lead to new insights into how arrhythmias develop and pave the way for targeted therapies that address the root causes of these conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the genetic causes of cardiac arrhythmias, improving patient outcomes.
How similar studies have gone: Other research has shown promise in linking genetic variants to heart conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Tucker, Nathan R — Upstate Medical University
- Study coordinator: Tucker, Nathan R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.