Understanding genetic factors that cause heart rhythm problems
From variants to mechanisms for cardiac arrhythmias
This study is looking at how certain genes might affect the chances of having irregular heartbeats, and it's for anyone interested in understanding more about heart health and potential new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-11226706 on NIH RePORTER |
What this research studies
This research investigates how specific genetic variations are linked to the risk of developing cardiac arrhythmias, which are irregular heartbeats. By using advanced techniques like CRISPR-Cas9 to modify gene expression and single nucleus RNA sequencing on human heart tissue, the researchers aim to uncover the biological mechanisms behind these genetic associations. This could lead to new insights into how arrhythmias develop and pave the way for targeted therapies that address the root causes of these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of cardiac arrhythmias or those who have experienced irregular heartbeats.
Not a fit: Patients without any genetic predisposition to cardiac arrhythmias or those with arrhythmias caused by non-genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the genetic causes of cardiac arrhythmias, improving patient outcomes.
How similar studies have performed: Other research has shown promise in linking genetic variants to heart conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Tucker, Nathan R — Upstate Medical University
- Study coordinator: Tucker, Nathan R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.