Understanding genetic factors linked to heart risks in children with kidney disease
Official title: Identifying genetic drivers of circulating metabolites associated with cardiac risk in pediatric chronic kidney disease
Funded at Children's Hosp of Philadelphia · NIH-10891713 · Data updated 2026-11-12
This study is looking at how genes and certain substances in the blood can affect heart health in kids with chronic kidney disease, hoping to find clues that could help prevent heart problems in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $105,867 |
| NIH project number | 5K38HL169660-02 |
| Project ID | NIH-10891713 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with chronic kidney disease, particularly those under the age of 18.
✕Less likely to help
Patients without chronic kidney disease or those over the age of 18 may not benefit from this research.
What this research studies
This research investigates the genetic and biochemical factors that contribute to heart problems in children suffering from chronic kidney disease (CKD). By analyzing blood samples, the study aims to identify specific genetic variations that influence levels of metabolites associated with heart health. The researchers will use advanced techniques, including metabolomics and genome-wide association studies, to explore how these metabolites affect heart conditions like left ventricular hypertrophy and ventricular dysfunction. The goal is to uncover potential markers for early intervention and prevention of cardiac issues in this vulnerable population.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing heart disease in children with chronic kidney disease.
How similar studies have gone: Previous research in metabolomics and genetic associations has shown promise in understanding cardiovascular risks, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Lee, Arthur — Children's Hosp of Philadelphia
- Study coordinator: Lee, Arthur
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.