Understanding genetic factors influencing Alzheimer's disease and related dementias
Official title: Investigating Cis- and Trans-Genetic Regulation of Brain Transcriptomics and Proteomics Associated with AD/ADRD
Funded at Emory University · NIH-11142778 · Data updated 2026-11-12
This study is looking at how our genes affect brain activity and protein production in Alzheimer's disease and similar conditions, with the hope of finding new ways to help patients by discovering more about the genes that might increase the risk of these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | June 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $528,876 |
| NIH project number | 1R01AG089703-01A1 |
| Project ID | NIH-11142778 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for Alzheimer's disease or those diagnosed with Alzheimer's or related dementias.
✕Less likely to help
Patients with non-genetic forms of dementia or those without any familial history of Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the genetic regulation of brain activity and protein production related to Alzheimer's disease and related dementias. By integrating various genomic data, the study aims to identify additional risk genes and understand their roles in the disease's progression. The approach includes analyzing data from multiple brain tissues and validating findings through computational methods and biological experiments. Patients may benefit from insights that could lead to new therapeutic targets or preventive strategies.
Why it matters
Potential benefit: If successful, this research could lead to the identification of new genetic risk factors for Alzheimer's disease, potentially informing better prevention and treatment strategies.
How similar studies have gone: Previous research has successfully utilized similar genomic integration approaches to uncover risk factors for other diseases, suggesting a promising avenue for this study.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Yang, Jingjing — Emory University
- Study coordinator: Yang, Jingjing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.