Understanding genetic factors in severe COVID-19 cases
Inborn errors of immunity in patients with life-threatening COVID-19
This study is looking at how certain genetic factors might make some people more likely to have severe reactions to COVID-19, and it's for anyone who wants to understand why some patients get sicker than others and how we can improve care for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10886556 on NIH RePORTER |
What this research studies
This research investigates how certain genetic factors, known as inborn errors of immunity, contribute to severe reactions in patients infected with COVID-19. By analyzing a diverse group of patients, the study aims to identify specific genetic mutations and autoantibodies that may lead to life-threatening symptoms. The approach includes international collaboration to gather data and samples from affected individuals, which will help in understanding the immune response to the virus. This could lead to better diagnostic tools and treatments for those at risk of severe COVID-19.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced severe COVID-19 symptoms or have a family history of immune-related conditions.
Not a fit: Patients with mild or asymptomatic COVID-19 infections are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved identification and treatment options for patients at risk of severe COVID-19 due to genetic factors.
How similar studies have performed: Previous studies have shown promising results in identifying genetic factors related to severe viral infections, suggesting that this approach could yield significant insights.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Casanova, Jean-Laurent — Rockefeller University
- Study coordinator: Casanova, Jean-Laurent
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.